A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome

by | Jun 3, 2026 | Uncategorized | 0 comments

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Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.

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