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How long-term dietary cholesterol can slow down its own clearance by liver cells

by Suzi Wilson | Jun 25, 2026 | Uncategorized | 0 comments

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Nature, Published online: 25 June 2026; doi:10.1038/d41586-026-01899-6

Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has been discovered through which high cholesterol promotes the enzyme-mediated degradation of LDLR. Blocking this enzyme restores LDLR levels in liver cells, suggesting a new strategy for treating high cholesterol.

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